Nuyens is a surname. Notable people with the surname include:
Nick Nuyens (born 1980), Belgian cyclist Wilhelmus Nuyens (1823-1894), Dutch historian
See also Wijnand Nuijen (1813-1839), Dutch painter and printmaker Martijn Nuijens (born 1983), Dutch track and field athlete France Nuyen (born 1939), French-American actress, model, and psychological counselor Nguyen, a Vietnamese surname