NGC 3278 is a spiral galaxy in the constellation of Antlia. Its velocity with respect to the cosmic microwave background is , which corresponds to a Hubble distance of . However, four non-redshift measurements give a closer mean distance of . It was discovered by British astronomer John Herschel on 2 March 1835.

NGC 3278 has a possible active galactic nucleus, i.e. it has a compact region at the center of a galaxy that emits a significant amount of energy across the electromagnetic spectrum, with characteristics indicating that this luminosity is not produced by the stars.

LDC 725 group NGC 3278 is a member of a group of galaxies known as LDC 725. This group contains 28 galaxies, including NGC 3244, , NGC 3256, NGC 3261, , , and , among others.

Supernova One supernova has been observed in NGC 3278: SN 2009bb (TypeIc, mag. 17.0) was discovered by The CHilean Automatic Supernova sEarch (CHASE) on 21 March 2009.

See also List of NGC objects (3001–4000)

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