Agyekum is a surname. Notable people with the name include:
Joseph Kwaku Afrifah-Agyekum (born 1954), Ghanaian Catholic prelate Alex Kofi Agyekum (born 1962), Ghanaian politician and member of parliament Beryl Agyekum, Ghanaian Digital Marketer, Founder and CEO of Echo House Ghana Limited Daniel Ohene Agyekum (born 1942), Ghanaian diplomat, politician and ambassador Dennis Agyekum (born 1996), Ghanaian footballer Emil Agyekum (born 1999), German hurdler and sprinter Emmanuel Kwadwo Agyekum, Ghanaian politician and a member of parliament Jeremie Agyekum Frimpong (born 2000), Dutch professional footballer John Agyekum Kuffuor (born 1938), Ghanaian politician, President of Ghana, Junior Agyekum (born 2002), Canadian soccer player Kofi Okyere-Agyekum (born 1958), Ghanaian politician and member of parliament Kwame Poku Agyekum, Ghanaian politician and member of parliament Lawrence Agyekum (born 2003), Ghanaian professional footballer Mark Agyekum (born 1992), Ghanaian professional footballer Owusu Agyekum (born 1942), Ghanaian politician and a member of parliament Forster-Khiz Agyekum, Ghanaian banking professional
See also FPSO John Agyekum Kufour, floating production storage and offloading (FPSO) vessel