Toshio Hoshino (10 December 1899 – 11 February 1979) is a Japanese chemist who specialized in natural product and polymer chemistry. He was a professor at the Tokyo Institute of Technology. Among other contributions, Hoshino, along with his colleague Kenya Shimodaira, is notable in being the first to synthesize the psychedelic tryptamines bufotenin (5-HO-DMT) and 5-MeO-DMT (mebufotenin) in 1935 and 1936, respectively. However, the hallucinogenic effects of these compounds and of tryptamines generally did not become known until much later in the 1950s and thereafter.Gessner, P. K. (1970). Pharmacological Studies of 5-Methoxy-N,N-dimethyltryptamine, LSD and Other Hallucinogens. Psychotomimetic Drugs, 105–118. https://www.samorini.it/doc1/alt_aut/ek/gessner-pharmacological-studies-of-5-methoxy-dimethyltryptamine-lsd.pdf#page=2 "DR. SHULGIN: We have [5-MeO-DMT] in clinical trial now. It is much more active than dimethyltryptamine. It is much less active than LSD and it is only active parenterally, as is the case with DMT. This is about all I can say. DR. SNYDER: How does it compare with psilocin? DR. SHULGIN: It is more active than psilocin, but I can't say how much more with any confidence. DR. GESSNER: This is all in accord with our data. DR. SHULGIN: We used 5 to 10 mg of 5-methoxy-N,N-dimethyltryptamine; perhaps even a lower dose can be used."

See also List of psychedelic chemists

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