GME may refer to:
Companies GameStop (stock ticker symbol GME), an American video game retailer General Microelectronics, a defunct American semiconductor manufacturer General Motors Egypt General Motors Europe Green Mountain Energy, American company Guardian Media Entertainment, collaboration between the National Hockey League and comics creator Stan Lee
Education Gaelic medium education in Scotland Graduate medical education
Other East Germanic languages FCA Global Medium Engine, an engine from Stellantis GME of Deutscher Wetterdienst, weather prediction model of the German Weather Service Generic Modeling Environment, software modelling tool Granulomatous meningoencephalitis, disease of the central nervous system of dogs and, rarely, cats Greater Middle East, a region