The 2025–26 USC Upstate Spartans women's basketball team represented the University of South Carolina Upstate during the 2025–26 NCAA Division I women's basketball season. The Spartans, led by fourth-year head coach Jason Williams, played their home games at the G. B. Hodge Center in Spartanburg, South Carolina as members of the Big South Conference.

Previous season The Spartans finished the 2024–25 season 9–21, 6–10 in Big South play, to finish in ninth (last) place. They were defeated by Longwood in the quarterfinals of the Big South tournament.

Preseason On October 15, 2025, the Big South Conference released their preseason poll. USC Upstate was picked to finish sixth in the conference.

Preseason rankings +Big South Preseason Poll Place Team Votes 1 77 (6) 2 69 (1) 3 67 (1) 4 48 5 41 6 USC Upstate 33 7 25 8 23 9 22 (1)

Source:

Preseason All-Big South Teams Preseason All-Big South TeamsTeamPlayerYearPositionSecondCassie Gallagher SophomoreGuard Source:

Roster

Schedule and results

!colspan=12 style=""| Non-conference regular season

!colspan=12 style=""| Big South regular season

!colspan=9 style=""|

Sources:

References