Marie-Ernestine is a feminine compound given name. Notable people bearing the name include:
Marie-Ernestine Juillard (1885–1963), French World War I heroine Marie-Ernestine Serret (1812–1884), French painter
See also Marie Ernestine Lavieille (1852–1937), French painter Maria Ernestine Walsh-Held (1881–1973), Swiss botanist and entomologist