Mossell is a surname and a given name. Notable people with the name include:
Given name: Sadie Mossell Alexander (1898–1989), pioneering black professional and civil rights activist Mary Mossell Griffin (1882–1968), American writer, clubwoman and suffragist
Surname: Aaron Albert Mossell (1863–1951), African-American lawyer Gertrude Bustill Mossell (1855–1948), American journalist, author, teacher and activist Mary Ella Mossell (1853–1886), American African Methodist Episcopal missionary in Haiti Nathan Francis Mossell (1856–1946), African-American physician