Trimethyllead chloride is an organolead compount with formula . It is a highly toxic colorless liquid.

Synthesis Trimethyllead chloride can be synthesized by reacting tetramethyllead with hydrogen chloride.

Uses Trimethyllead chloride is primarily used in organic synthesis and as a reagent in various chemical reactions, particularly in the preparation of organolead compounds.

Biochemistry Trimethyllead chloride inhibits δ‐aminolevulinic acid dehydratase (ALAD) in vitro, although to a lesser extent than triethyllead chloride.

Reactions Trimethyllead chloride reacts with hexamethyldilead to yield tetramethyllead and lead(II) chloride.

Hazards As typical of organolead compounds, trimethyllead chloride is a poison. It is highly toxic to the environment, with long-lasting effects.

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