David Isserman (born March 31, 1983) is an American entrepreneur and conservationist living in Lisbon, Portugal. He is the founder of Isserman Ventures, which describes itself as working with e-commerce brands to build and scale their operations.
Isserman co-founded RareShare, an online platform for rare disease communities, in 2008, and founded Venin Royale, a skincare company in Boulder, Colorado, in 2013.
From 2020 to 2026, he served on the board of directors of The Explorers Club, and he helped form the club's Portugal Chapter. In 2024, he carried an Explorers Club flag on an expedition that reintroduced endangered Sorraia horses to Portugal's Alentejo region, and in 2025 he led a team on the Dino Dawn paleontological expedition in the Algarve. In 2023, Duarte Pio, Duke of Braganza made him a Knight of the Order of Saint Michael of the Wing.
Early life and education Isserman grew up in Clayton, Missouri, and graduated from Clayton High School in 2001. He began building websites for small businesses in middle school and had about 75 clients by high school. At age 14, he approached A.G. Edwards to offer technology consulting services; Alfred Goldman, a corporate vice president at the firm's brokerage subsidiary, later nominated him for the St. Louis Business Journals 30 Under 30 list, to which he was named in 2006. He earned a Bachelor of Science from Indiana University and an MBA from Columbia Business School.
Career
Early ventures While at Indiana University, Isserman founded Isserman Consulting LLC, a communications and web strategy firm in Clayton. In 2006, television host Richard Wiese hired the firm to build his web presence, including a site for Wiese's nationally syndicated show Exploration with Richard Wiese.
RareShare In 2008, while attending Columbia Business School, Isserman co-founded RareShare with Eric Steele. The platform connected people affected by rare diseases with one another and with medical professionals. RareShare won the social venture category at the 2008 Pace Pitch Contest hosted by Pace University's Lubin School of Business. In December 2008, TechCrunch reported that the platform had more than 700 communities for different disorders and that, according to RareShare, it had been collaborating with the National Institutes of Health and the Canadian Organization for Rare Disorders. The Washington Post covered the platform in February 2009, and the Toronto Star reported that it hosted discussion groups for hundreds of conditions. RareShare grew to more than 850 communities before Isserman exited in 2014. RareShare is now operated by the Rare Genomics Institute, which describes it as having more than 1,000 disease communities. The platform has been cited in the academic literature on rare-disease drug discovery.
Venin Royale In 2013, Isserman founded Venin Royale, a skincare company in Boulder, Colorado, that used king cobra venom peptides in its products. The products were developed with neuroscientist Paul Reid. The line was sold through physician offices, medical spas, and specialty retailers.
Isserman Ventures Isserman is the founder of Isserman Ventures, which describes its work with e-commerce brands as including supply chain management, logistics, international distribution, manufacturing oversight and brand development. Town and Style reported in 2023 that the firm also makes angel investments in scientists and entrepreneurs and provides microgrants to local conservation efforts.
Exploration and conservation Isserman is a graduate of the National Outdoor Leadership School. He joined The Explorers Club in 2002 and is a life member. From March 2020 to April 2026, he served on the club's board of directors. He chaired the club's annual dinner (ECAD) and co-chaired its Conservation and Sustainability Committee. After the club's 2023 Global Exploration Summit (GLEX) in the Azores, Isserman and the chapter's founding chair led the formation of the club's Portugal Chapter. The club's November 2025 announcement of its mobile app thanked him for guidance in modernizing its data infrastructure and digital footprint.
In November 2024, Isserman carried Explorers Club Flag No. 179 on an expedition to reintroduce endangered Sorraia horses to a former cattle ranch in Vila Viçosa, in the Alentejo. The ranch is the designated site of an elephant sanctuary run by Pangea Trust, a UK-registered charity.
He returned the flag at the club's ECAD Sunday flag-return ceremony in April 2025.
In 2025, Isserman led the PaleoDiscovery Team on the Dino Dawn Expedition, an Explorers Club flag-bearing paleontological dig in Portugal's Algarve region whose lead paleontologist is Ricardo Araújo.
Affiliations and honors Isserman is an advisory trustee of the Academy of Science of St. Louis.
In 2023, Duarte Pio, Duke of Braganza, made Isserman a Knight of the Order of Saint Michael of the Wing, a dynastic order of the non-reigning House of Braganza.
Personal life Isserman married Anna Berger in June 2014. They moved from the United States to Lisbon, Portugal, in 2022.
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