Biyela is a surname. Notable people with the surname include:
Bafo Biyela (1981–2012), South African football player Bhekizwe Biyela, South African politician Nokwethemba Biyela (born 1954), South African politician Ntsiki Biyela (born 1978), South African winemaker and businesswoman Thando Biyela (born 2004), South African rugby player Zimiphi Biyela (born 1983), South African actress