5-Hydroxyindoline, also known as 2,3-dihydro-1H-indol-5-ol, is a psychoactive substance, saturated (hydrogenated) derivative of indole, which has a hydroxyl group in the 5th position of the benzene ring, structurally belong to the family of indoline derivatives.
Pharmacology 5-Hydroxyindoline has shown superior results as a dopamine D4 receptor ligand, with more selective binding than classical dopaminergic drugs. It is a D4 receptor agonist.
Other studies have shown that 5-hydroxyindoline is an inhibitor of the D2 dopamine receptor.
Occurrence 5-Hydroxyindoline was found and isolated from Phoebe chekiangensis.
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