2CT2-2-EtO, also known as 2-ethoxy-4-ethylthio-5-methoxyphenethylamine, is a psychedelic drug of the phenethylamine, 2C, and TWEETIO families related to 2C-T-2. "All three Tweetios of 2C-T-2 have been made and looked at through human eyes. The 2-EtO-homologue of 2C-T-2 is 2-ethoxy-4-ethylthio-5-methoxyphenethylamine, or 2CT2-2ETO. The benzaldehyde (2-ethoxy-4-ethylthio-5-methoxybenzaldehyde) had a melting point of 73-75 °C, the nitrostyrene intermediate a melting point of 122-123 °C, and the final hydrochloride a melting point of 202-204 °C. Fifty milligrams was a completely effective level. The effects were felt very quickly. Vision was blurred, and there were intense eyes-closed visuals and the generation of a pleasant, contemplative mood. Baseline was re-established in five or six hours, but sleep was restless, with weird dreams. Nasal administration showed considerable variation between individuals, but a typical dose was 10 milligrams." It is the derivative of 2C-T-2 in which the methoxy group at the 2 position has been replaced with an ethoxy group.
According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CT2-2-EtO has a "completely effective" dose of 50mg orally, a typical dose of 10mg intranasally but with considerable variation between individuals, and a duration of 5 to 6hours or of 9hours. Its onset is said to be "very quick". The effects of 2CT2-2-EtO have been reported to include blurred vision, intense closed-eye visuals, generation of a pleasant and contemplative mood, restless sleep, and weird dreams. Due to the large ~5-fold increase in potency when taken intranasally instead of orally, 2CT2-2-EtO may undergo substantial first-pass metabolism with oral administration.
The chemical synthesis of 2CT2-2-EtO has been described.
2CT2-2-EtO was first described in the literature by Shulgin in PiHKAL in 1991. It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.
See also TWEETIO (psychedelics)
References
External links 2CT2-2ETO - Isomer Design