United States post offices operate under the authority of the United States Post Office Department (1792–1971) or the United States Postal Service (since 1971). Historically, post offices were usually placed in a prominent location. Many were architecturally distinctive, including notable buildings featuring Beaux-Arts, Art Deco, and Vernacular architecture. However, modern U.S. post offices were generally designed for functionality rather than architectural style.

Following is a list of United States post offices in South Carolina. Notable post offices include individual buildings, whether still in service or not, which have architectural, historical, or community-related significance. Many of these are listed on the National Register of Historic Places (NRHP) or state and local historic registers.

Post officeCityDate builtImageArchitectNotesU.S. Post Office and Courthouse, now Sullivan-King MortuaryAnderson1909James Knox TaylorUnited States Post Office and Court House, now G. Ross Anderson Jr. Federal Building and CourthouseAnderson1937–1938Thomas Harlan EllettBamberg Post OfficeBamberg1937–1938Louis A. SimonUnited States Post Office (Batesburg-Leesville, South Carolina)Batesburg-Leesville1939Louis A. Simon, Neal A. MelickUnited States Post Office (Bishopville, South Carolina)Bishopville 1940United States Post Office and Courthouse (Charleston, South Carolina)Charleston1896John Henry DevereuxUnited States Post Office (Chesterfield, South Carolina)Chesterfield1937–1938Louis A. SimonOld Clemson Post Office, now Mell HallClemson1940United States Post Office (Easley, South Carolina)Easley1940Louis A. Simon, Neal A. MelickUnited States Post Office (Florence, South Carolina)Florence1906C.F. Haynsworth Federal Building and United States CourthouseGreenville1936–1937Eric KebbonUnited States Court House and Post Office, later the Greenville City HallGreenville1889James H. WindrimFederal Building (Greenwood, South Carolina), now Arts Center and Visitor CenterGreenwood1909–1910Greer Post Office, now Greer Heritage MuseumGreer1935Donald G. Anderson, Louis A. SimonHartsville Post OfficeHartsville1930James A. Wetmore, Ernest C. StewardUnited States Post Office (Kingstree, South Carolina)Kingstree1937–1938Monticello Store and Post OfficeMonticellounknownPrice's Post OfficeMooreunknownUnited States Post Office (Mullins, South Carolina)Mullins1939formerUnited States Post Office and Courthouse (Rock Hill, South Carolina)Rock Hill1931–1932James A. WetmoreUnited States Post Office (Summerville, South Carolina)Summerville1938United States Post Office (Walterboro, South Carolina)Walterboro1936–1937United States Post Office (Ware Shoals, South Carolina)Ware Shoals1935United States Post Office (Winnsboro, South Carolina)Winnsboro1936–1937United States Post Office (Woodruff, South Carolina)Woodruff1939Louis A. Simon, Neal A. Melick

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