E22 may refer to: European route E22, a road extending from the United Kingdom to Russia GER Class E22, a British 0-6-0 steam tank locomotive class Etchells, a 22-foot sailboat Nimzo-Indian Defence, Encyclopaedia of Chess Openings code E22, a numbers station that was later discovered to simply be a repeated test broadcast run by All India Radio Senai–Desaru Expressway, route E22 in Malaysia