Khayelihle is a given name. Notable people with the name include:
Khayelihle Madlala (), South African politician Khayelihle Mathaba (died 2014), South African royal and politician Khayelihle Mthiyane (1944–2021), South African jurist and judge Khayelihle Shozi (born 1994), South African footballer Khayelihle Zondo (born 1990), South African cricketer
See also Khayelitsha