NGC 2721 is a barred spiral galaxy in the constellation of Hydra. Its velocity with respect to the cosmic microwave background is , which corresponds to a Hubble distance of . Additionally, 13 non-redshift measurements give a similar mean distance of . It was discovered by German-British astronomer William Herschel on 1 February 1786.

NGC 2721 is a Seyfert II galaxy, i.e. it has a quasar-like nucleus with very high surface brightnesses whose spectra reveal strong, high-ionisation emission lines, but unlike quasars, the host galaxy is clearly detectable.

Supernova One supernova has been observed in NGC 2721: SN 2024xjl (TypeIb/c, mag. 17.605) was discovered by ATLAS on 5 October 2024.

See also List of NGC objects (2001–3000)

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