The Afghan Rebellions of 1709–1726 were a series of uprisings in which the Ghilzai Hotakis exploited Safavid weakness to rebel in Kandahar, establish an independent Afghan state, and invade Persia. The Afghans captured major cities and forced the surrender of Isfahan in 1722.

These revolts included the Persian–Afghan War (1709–1711) and the Afghan conquest of Persia (1717–1722), culminating in Russian and Ottoman interventions in Persia and subsequent wars with Nader Shah.

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