Dergham, Dargham, or Dirgham ( ), is a given name and a surname literally meaning brave but also used as an Arabic epithet for lion. Notable people with the name include:
Dirgham (), Arab military commander Anissa Abi-Dargham (), American psychiatrist and researcher Joseph Dergham (1930–2015), Lebanese Bishop Joseph Dergham El Khazen (died 1742), 60th Maronite Patriarch of Antioch Raghida Dergham (born 1953), Lebanese-American journalist Ray Dargham (), Lebanese American businessperson