1-Benzyl-4-piperidone

1-Benzyl-4-piperidone, also called N-benzyl-4-piperidone, is a derivative of 4-piperidone.

Physical properties 1-Benzyl-4-piperidone is normally in liquid state with a yellow color. It also has a strong odor. Additionally, 1-benzyl-4-piperidone has a solubility of 12 g/L in water at room temperature.

Pharmaceutical chemistry usage Like the related compound 4-piperidone, 1-benzyl-4-piperidone can be used in the synthesis of fentanyl. While using 1-benzyl-4-piperidone as the starting precursor initially yields benzylfentanyl (which is considered as virtually inactive), the resulting compound can be converted to fentanyl, according to Paul Jassen's works.

Regulations As other drug precursors, 1-benzyl-4-piperidone is heavily regulated like its parent chemical. It is for example a compound on the DEA list and a Class A precursor under Canada's CDSA law.

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