Icafolin is a post-emergent chemical herbicide developed by Bayer. Its formula is . The herbicide was introduced in 2022, registered in 2025, and is anticipated to be introduced in 2028 for use in Brazil. It is a tubulin inhibitor that may be applied to soybeans, corn, and cotton among other crops. The chemical is synthesized as a mixture of (2R,4R) and (2S,4S) stereoisomers through a multi-step process.
Icafolin-methyl, a derivative methyl ester of icafolin, is also a tubulin inhibitor and is hydrolyzed to icafolin in plants.
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