The 2005–06 Nebraska Cornhuskers men's basketball team represented the University of Nebraska–Lincoln in the 2005–06 college basketball season. The Cornhuskers were coached by Barry Collier. The Cornhuskers competed in the Big 12 Conference and played their home games at the Bob Devaney Sports Center.
Nebraska lost to Florida State in the Orange Bowl Basketball Classic 74–60 on December 31, 2005.
They finished the season with a 19–14 record, losing in the Big 12 third round to Kansas 79-65 and lost in the 2006 NIT 1st round to Hofstra 73–62.
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