Asimakopoulou is a Greek surname. Notable people with the surname include:

Anna-Misel Asimakopoulou (born 1967), Greek politician and lawyer Beata Asimakopoulou (1932–2009), Greek actress Elena Asimakopoulou (), first runner-up in 2006 Miss Star Hellas competition Ioanna Asimakopoulou (born 1984), Greek actress