2C-B-3PIP-POMe is a serotonin receptor modulator of the phenethylamine, 2C, 3-phenylpiperidine (3PIP), and NBOMe families. It is a cyclized phenethylamine and along with 2C-B-3PIP-NBOMe is an NBOMe derivative of 2C-B-3PIP. The drug is a mixture of cis- and trans- isomers. Its isomers show weak affinity for the serotonin 5-HT2A and 5-HT2C receptors (Ki = 290–856nM and 3,850–23,200nM, respectively), with these affinities being profoundly reduced relative to those of 2C-B. The cis isomer is a low-potency agonist of the serotonin 5-HT2A receptor ( = 480–2,300nM; = 87–94%), the serotonin 5-HT2B receptor ( = 770nM; = 20%), and the serotonin 5-HT2C receptor ( = 170–2,000nM; = 80–82%), whereas the trans isomer is inactive as an agonist of these receptors even at very high concentrations. The chemical synthesis of 2C-B-3PIP-POMe has been described. 2C-B-3PIP-POMe was first described in the scientific literature by Martin Hansen in 2010.
See also Cyclized phenethylamine Substituted 3-phenylpiperidine Partial ergoline 2C-B-3PIP and 2C-B-3PIP-NBOMe 25B-NBOMe and DMBMPP (juncosamine) 2CBecca, 2CLisaB, and 2CJP
References
External links 2C-B-3PIP-POMe - Isomer Design