DIPK1B or divergent protein kinase domain 1B is a protein that in humans is coded by the DIPK1B gene. It is a member of the FAM69 family, which consists of three members across all vertebrates other than fish. It is also known as FAM69B.
Gene
The DIPK1B gene is found on human chromosome 9, in the 9q34.3 band. The gene is located on the plus strand and spans 12,275 bases. The gene contains five exons. It is a member of FAM69, a family of genes with three members, DIPK1A, DIPK1B, and DIPK1C. This family is present in all vertebrates, with slight differences in fish, and orthologs of highly conserved structure are found in all metazoa.
Transcripts
In humans there is only one known DIPK1B transcript. The mRNA transcript of DIPK1B is 2358 bases long, and contains all five exons of the DIPK1B gene. Protein
Human DIPK1B has only one isoform. The resultant protein is 431 amino acids long, has an isoelectric point of 9, and has a predicted molecular weight of 48.6 kDa. DIPK1B contains two distinct domains, a transmembrane domain and a protein kinase domain.
Expression DIPK1B exhibits variable ubiquitous expression at moderate to high levels. Expression in the brain, heart, and lung is notably higher than in other tissues.
Regulation DIPK1B is localized to the membrane of the endoplasmic reticulum. It is expected to undergo a number of post-translational modifications, including o-linked glycosylation, phosphorylation, ubiquitination, and acetylation.
Homology +DIPK1B OrthologsGenus and SpeciesCommon NameTaxonomic GroupDate of Divergence (MYA)Accession NumberSequence Length (aa)Sequence Identity to Human Protein (%)Sequence Similarity to Human Protein (%)Homo sapiensHumansPrimates0NP_689634431100100Gorilla gorilla gorillaGorillaPrimates8.6XP_004048941.243199.599.5Desmodus rotundusVampire batMammals94XP_05377513543584.990.7Dromiciops gliroidesMonito del monteMarsupials160XP_043845610.143171.283.5Gopherus flavomarginatusBolson tortoiseReptiles319XP_050782714.143168.282.6Tiliqua scincoidesCommon blue-tongued skinkReptiles319XP_066466737.143166.881.4Varanus komodoensisKomodo dragonReptiles319XP_044309118.143165.790Cyrtonyx montezumaeMontezuma quailBirds319XP_065593300.143167.582.6Gallus gallusChickenBirds319XP_41542343167.382.4Taeniopygia guttataAustralian zebra finchBirds319XP_002199526.443166.181.7Geothlypis trichasCommon yellowthroatBirds319KAL9827061.143165.982.4Ambystoma mexicanumAxolotlAmphibians352XP_069465698.143167.581Ascaphus trueiTailed FrogAmphibians352XP_07543502443166.182.6Xenopus laevisAfrican clawed frogAmphibians352XP_018088073.143162.980.3Protopterus annectensWest African LungfishFish408XP_04391447043165.482.4Hypanus sabinusAtlantic stingrayFish462XP_059850265.143161.580.3Callorhinchus miliiAustralian ghostsharkFish462XP_042193771.143160.878.4Amblyraja radiataThorny skateFish462XP_03290459943158.979.1Magallana gigasPacific OysterMollusks686XP_011453093.243823.740Anopheles gambiaeMosquitoInsects686XP_0614985264272337.3
Function DIPK1B has been shown to interact with SAT1 and SLC39A12.
References