Substitution method may refer to:

Substitution method (optical fiber), a way to calculate power loss in fiber optic cables Substitution method (optimization), the solution method to simple constrained optimization problems Substitution method (primary energy), a way to calculate the equivalent primary energy of a non fossil fuel source of electricity

See also Epsilon substitution method in calculus Weierstrass substitution method, a name sometimes used for tangent half-angle substitution in calculus Substitution (algebra) Substitution (logic)