2CB-2-EtO, also known as 4-bromo-2-methoxy-5-ethoxyphenethylamine, is a psychedelic drug of the phenethylamine, 2C, and TWEETIO families related to 2C-B. "There are two “Tweetios” known that are related to 2C-B. (See recipe #23 for the origin of this phrase.) The 2-EtO- homologue of 2C-B is 4-bromo-2-ethoxy-5-methoxyphenethylamine, or 2CB-2ETO. The unbrominated benzaldehyde (2-ethoxy-5-methoxybenzaldehyde) had a melting point of 47.5–48.5 °C, the unbrominated nitrostyrene intermediate a melting point of 76–77 °C, and the final hydrochloride a melting point of 185–186 °C. The hydrobromide salt had a melting point of 168.5–169.5 °C. It seems that one gets about as much effect as can be had, with a dosage of about 15 milligrams, and increases above this, to 30 and to 50 milligrams merely prolong the activity (from about 3 hours to perhaps 6 hours). At no dose was there an intensity that in any way resembled that of 2C-B." It is the derivative of 2C-B in which the methoxy group at the 2 position has been replaced with an ethoxy group.
According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CB-2-EtO produces maximal effects at a dose of about 15mg orally. Higher doses of 30 to 50mg orally did not increase its effects any further but only prolonged their duration, from about 3hours to perhaps 6hours. 2CB-2-EtO was said to have not had an intensity that resembled that of 2C-B at any dose. It was also said to be dramatically or about 5-fold less potent than 2C-B. Beyond the preceding, the specific effects of 2CB-2-EtO were not described.
The chemical synthesis of 2CB-2-EtO has been described.
2CB-2-EtO was first described in the literature by Shulgin in PiHKAL in 1991. It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.
See also TWEETIO (psychedelics) 2CD-5EtO 2CB-5PrO (ASR-2001)
References
External links 2C-B-5-EtO - Isomer Design