Centelles is a Spanish surname. Notable people with the surname include:
Agustí Centelles (1909–1985), Catalan photographer Álex Centelles (born 1999), Spanish footballer Francisco Centelles (1961–2025), Cuban high jumper Gilabert de Centelles y de Cabrera (born c. 1400), a Viceroy of Sicily Girolamo Centelles, Roman Catholic Archbishop of Reggio Calabria (1529–1535)
See also Andrea Di Giovanni y Centellés (1742–1821), Sicilian nobleman of Spanish descent Francisco Antonio de Borja-Centelles y Ponce de Léon (1659–1702), Spanish cardinal