Schaikewitz is an Ashkenazi Jewish surname. It is an East-Slavic-style patronymic derivation from the given name Shaike. Notable people with the surname include:
Nahum Meir Schaikewitz (1849–1905, Yiddish and Hebrew novelist and playwright. Mia Schaikewitz (born 1978), American TV personality and spokesperson for disability advocacy
See also
Szajewicz, Shayevich; surnames derived from another diminutive, Shaya