The House of Guicciardini () is an old and important Florentine family, which originated from Mugello as rich landowners and moved to Florence in the 14th century. When Francesco Guicciardini (1851–1915) married Princess Luisa Strozzi-Majorca-Renzi (1859–1933), this line of the family changed its name to Guicciardini-Strozzi.
Notable members Francesco Guicciardini (1483–1540), Italian historian and statesman Lodovico Guicciardini (1521–1589), his nephew, Italian historian active in Antwerp Francesco Guicciardini (politician) (1851–1915), Italian politician Niccolò Guicciardini (born 1957), Italian historian of mathematics
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