A-NK, or alkyne-norketamine, is a designer drug from the arylcyclohexylamine family. It is derived from norketamine, a major metabolite of ketamine. It acts as a non-competitive NMDA antagonist, with comparable effects to ketamine.

Pharmacology

Pharmacodynamics A-NK acts as an antagonist at the PCP site of NMDA receptors. The effects depend on the presence of a protonable nitrogen atom, with A-NK-amide showing substantially lower activity at NMDA receptors. The potency of A-NK at NMDA receptors has been shown to be roughly 4 times lower than ketamine.

See also 2-FXPr SN 35210

References