4-MeO-DET

4-MeO-DET, also known as 4-methoxy-N,N-diethyltryptamine, is a chemical compound of the tryptamine and 4-methoxytryptamine families related to psilocin (4-HO-DMT). "The 4-methyl ether of psilocin, 4-MeO-DMT, is especially appealing, in that it is a simple homologue of psilocin and it is quite stable. But the methyl group as an ether link lacks the lability of the phosphate or acetate esters, and it cannot be easily hydrolyzed off to form psilocin. The immediate homologue is 4-MeO-DET which is completely without action either orally or by smoking at dosages up to 30 mgs. The two remaining DMT isomers are with the methoxy at the 6-position (to give 6-MeO-DMT originally thought to be a minor alkaloid in B. caapi) and at the 7-position (to give 7-MeO-DMT which was observed as a minor impurity in the preparation of 7-MeO-MIPT)." It is the 4-methoxy derivative of diethyltryptamine (DET), the O-methyl ether 4-HO-DET (ethocin), and a positional isomer of 5-MeO-DET.

Use and effects According to Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved), 4-MeO-DET is completely inactive at doses of up to 30mg orally or smoked. Hence, its dose range is unknown but greater than 30mg and its duration is unknown. Higher doses were not assessed.

Chemistry Analogues Analogues of 4-MeO-DET include diethyltryptamine (DET), 4-methoxytryptamine (4-MT or 4-MeO-T), 4-HO-DET (ethocin), 4-AcO-DET (ethacetin), 5-MeO-DET, 4-MeO-DMT, 4-MeO-DiPT, 4-MeO-MiPT, and 4-methyl-DMT, among others. 4-MeO-MiPT is known to be active, producing erotic-enhancing effects but little in the way of visuals, whereas 4-MeO-DMT and 4-MeO-DiPT have been found to be active in preclinical research but have not been tested in humans.

History Aside from 4-MeO-DET's description in Alexander Shulgin's 1997 book TiHKAL (Tryptamines I Have Known and Loved), 4-MeO-DET does not appear to have been otherwise described in the literature.

4-MeO-DET

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