Prinsen is a surname. Notable people with the surname include:
François Prinsen (1905-?), Belgian sprinter Henk Prinsen (born 1951), Dutch racing cyclist Joost Prinsen (1942–2025), Dutch actor, television presenter, singer, and writer Lesmond Prinsen (born 1973), Dutch football player Tim Prinsen (born 1971), Canadian football player and coach Tom Prinsen (born 1982), Dutch long track speedskater Wim Prinsen (1945–1977), Dutch racing cyclist
See also Prinsen Geerligs, another surname