Charmian, also known as α-methyl-DOM, α,α,4-trimethyl-2,5-dimethoxyphenethylamine, or BL-4041A, is a serotonin receptor modulator of the phenethylamine, amphetamine, phentermine, and DOx families related to DOM. "Replacing the alpha-hydrogen of DOM with a methyl group would give the phentermine analogue which is named CHARMIAN. You may be thinking of Cleopatra’s favorite attendant, but I was thinking of the sweet wife of a very dear friend of mine, a lady who has been in a state of gentle schizophrenia for some forty years now. The MDA analogue of CHARMIAN has been described in this foornote under the code name of MDPH. CHARMIAN, herself, has been synthesized and is of very much reduced potency in animals, as compared to DOM. It has not been tried in man as far as I know." It is the α-methyl derivative of DOM or the 4-methyl-2,5-dimethoxy derivative of phentermine. According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved), Charmian was synthesized and studied and was found to be of greatly reduced affinity for serotonin receptors and potency in animals compared to DOM. It is not known to have been tested in humans. The drug is one of Shulgin's "ten classic ladies", a series of methylated DOM derivatives. The chemical synthesis of Charmian has been described. Charmian was first described in the scientific literature by C. F. Barfknecht and colleagues in 1978.Barfknecht, CF; Caputo, JF; Tobin, MB; Dyer, DC; Standridge, RT; Howell, HG; Goodwin, WR; Partyka, RA; Gylys, JA; Cavanagh, RL. (1978). Congeners of DOM: Effect of distribution on the evaluation of pharmacologic data. QuaSAR: Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists, and Hallucinogens. NIDA Research Monograph 22. https://isomerdesign.com/bitnest/external/Books/NIDA22.16 The drug is not an explicitly controlled substance in the United States, but may be considered scheduled as an isomer of DOET.
See also DOx (psychedelics) MDPH (α-methyl-MDA)
References
External links Charmian (α-Me-DOM) - Isomer Design