N-sec-Butyltryptamine (NsBT) is a psychoactive drug of the tryptamine family related to psychedelics like dimethyltryptamine (DMT). https://erowid.org/library/books_online/tihkal/tihkal49.shtml "The two geometric isomers, mono-isobutyl and mono-sec-butyl tryptamines are best called NIBT and NSBT. They also have been made by the oxalylamide route and the hydrochloride salts melt at 150-151 °C and 175-177 °C resp. Interestingly, NSBT is one of the two mono-substituted tryptamines that just might have CNS activity. It has shown a generalized and somewhat diffuse intoxication with several studies covering the 25 to 75 milligram range. Short lived, intellectual excitement with some modest sensory enhancements. Promising, and a lot of erotic horniness, but no plus threes, yet." [...] "The tertiary-butyl analogue, NTBT, is the remaining mono-substituted tryptamine that just might have psychotropic potential. In the 5 to 20 milligram area, there is a light-headed intoxication that is a totally pleasant buzz, but nothing more profound than that. Wouldn't it be fascination of it turned out that all of the mono-tryptamines (the NRT's) were GHB-like intoxicants, and totally devoid of psychedelic activity. That would be a true challenge to the SAR crowd. I was told many years ago that NTBT was extremely potent when smoked, but I never received any particulars, and I must leave that as a baseless rumor."

Use and effects NsBT was briefly described by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved). According to Shulgin, NsBT is active at a dose of 25 to 75mg orally and has a short-lived duration. Its effects included a generalized and somewhat diffuse intoxication, intellectual excitement, modest sensory enhancements, and "a lot of erotic horniness". However, no "plus-three" ratings occurred on the Shulgin Rating Scale.

Shulgin has said that along with N-tert-butyltryptamine (NtBT), it is one of only two N-mono-substituted tryptamines with known psychoactivity. He also said that N-mono-substituted tryptamines might be GHB-like intoxicants devoid of psychedelic effects. However, N-methyltryptamine (NMT) has been reported to produce psychedelic effects.

Chemistry Analogues Analogues of NsBT include 5-MeO-NsBT, N-methyltryptamine (NMT), N-ethyltryptamine (NET), N-isopropyltryptamine (NiPT), N-benzyltryptamine (NBnT), N-methyl-N-sec-butyltryptamine (MsBT), among others.

Society and culture Legal status Canada NsBT is not a controlled substance in Canada as of 2025.

See also Substituted tryptamine

References

External links NSBT - Isomer Design