Werthein is a surname. Notable people with this surname include:
Gerardo Werthein (born 1955), Argentine businessman and diplomat Gregorio Werthein (born 1983), Argentine equestrian Judi Werthein (born 1967), Argentine artist Lucas Werthein (born 1981), Argentine equestrian
See also Werthein Group, Argentine holding company Wertheins Corner, New Jersey, United States, an unincorporated community