1-Methyl-2-iodo-LSD (MIL) is a serotonin receptor modulator of the lysergamide family related to lysergic acid diethylamide (LSD). It is the 1-methyl derivative of 2-iodo-LSD (IOL). Extensive metabolism of other 1-methylated lysergamides to their secondary amine derivatives, for instance methysergide (1-methylmethylergometrine) conversion into methylergometrine, has been observed. The properties and effects of MIL in humans are unknown. However, a radiolabeled form of MIL, 1-methyl-2-[125I]iodo-LSD ([125I]-MIL), as well as the analogue 1-ethyl-2-[125I]iodo-LSD ([125I]-EIL), have been developed for use as presumably non-hallucinogenic agents in imaging of serotonin receptors. [125I]-MIL has much greater selectivity for serotonin 5-HT2 receptors over dopamine receptors compared to LSD. MIL and [125I]-MIL were first described in the scientific literature by Beth J. Hoffman and colleagues by 1985.
See also Substituted lysergamide 2-Iodo-LSD MBL-61 (1-methyl-2-bromo-LSD) BOL-148 (2-bromo-LSD) 1P-BOL-148 MLD-41 (1-methyl-LSD) Methysergide
References
External links 2-Iodo-1-methyl-LSD (MIL) - Isomer Design LSD-25 (Discusses MIL) - TiHKAL - Erowid LSD-25 (Discusses MIL) - TiHKAL - Isomer Design