Sysonby may refer to:

Sysonby (horse) (1902–1906), an American Thoroughbred racehorse Sysonby, Leicestershire, England Sysonby Handicap, a horse race named after the horse Baron Sysonby, a title in the Peerage of the United Kingdom Victoria Ponsonby, Baroness Sysonby (1874 – 1955), a British cookbook author