2C-T-35, also known as 2C-T-DFM or as 4-difluoromethylthio-2,5-dimethoxyphenethylamine, is a designer drug from the substituted phenethylamine family, which was first synthesised by Josh Hartsel and colleagues in 2024. It is a potent agonist at the serotonin receptor 5-HT2A in vitro, with a binding affinity (Ki) of 6.3 nM. In animal studies, 2C-T-DFM was the most effective compound at producing a head-twitch response out of a series of related analogues, with an average of 33 head-twitches per 10 minutes compared to 21 for 2C-T-TFM. While it had previously been proposed as a theoretical compound, 2C-T-35 is not known to have been tested in humans. It is a controlled substance in Canada under phenethylamine blanket-ban language.
See also 2C (psychedelics) 2C-T-21.5 2C-T-29
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