Mohedano is a surname and a given name. Notable people with the name include:
Surname: Andrés García Mohedano (born 1996), Spanish professional footballer Antonio Mohedano (1561–1625), Spanish painter of the Renaissance period David Gil Mohedano (born 1994), Spanish professional footballer Elena Congost Mohedano (born 1987), T12/B2 track and field athlete from Spain Lourdes Mohedano (born 1995), Spanish group rhythmic gymnast Oriol Mohedano, Spanish football manager/head coach Rafael Rodríguez Mohedano (1725–1787), Spanish Franciscan, historian and writer
Given name: José María Mohedano Fuertes (born 1948), Spanish lawyer and politician Rocio Mohedano Jurado (1943–2006), Spanish singer and actress