Desnica is a surname and a masculine given name. Notable people with the name include:

As a surname Damir Desnica (born 1956), Croatian footballer Uroš Desnica (politician) (1874–1941), Yugoslav politician Uroš Desnica (scientist) (1944–2021), Croatian physicist Vladan Desnica (1905–1967), Serbian writer

As a given name Desnica Radivojević (born 1952), Bosnian politician

See also