Safarzadeh is a surname. Notable people with the surname include:
Abouzar Safarzadeh (born 1995), Iranian footballer Hajar Safarzadeh (born 2000), Iranian para-athlete Jamshid Safarzadeh (born 1982), Iranian santur player and composer Mehrdad Safarzadeh (born 1962), Iranian former cyclist Saeid Safarzadeh (born 1985), Iranian cyclist Siamak Safarzadeh (born 1964), Iranian former cyclist