2025 US Open – Wheelchair men's doubles

Gustavo Fernández and Tokito Oda defeated Alfie Hewett and Gordon Reid in the final, 6–1, 2–6, [10–6] to win the men's doubles wheelchair tennis title at the 2025 US Open.

Stéphane Houdet and Takashi Sanada were the reigning champions, but Sanada did not participate this year. Houdet partnered Takuya Miki, but lost in the semifinals to Hewett and Reid.

There was no edition of the event in 2024 due to a scheduling conflict with the 2024 Summer Paralympics.