Afonso is a surname which may refer to:
Andrey Nazário Afonso, known as Andrey (footballer, born 1983), Brazilian footballer Ana Afonso (1976–2024), Portuguese model and actress Diogo Afonso, 15th century Portuguese explorer Eddie Afonso (born 1994), Angolan footballer Guilherme Afonso (born 1985), Angolan footballer João Afonso (disambiguation) Jorge Afonso (c. 1470–1540), Portuguese Renaissance painter José Afonso (1929–1987), Portuguese folk singer-songwriter Kiki Afonso (born 1994), Portuguese footballer Leo Afonso (born 2001), Brazilian footballer Leoncio Afonso (1916–2017), Spanish professor of geography Manuel Afonso (1917–2000), Portuguese football manager Martim Afonso, baptismal name of Arariboia (c. 1520–1589), leader of the Temiminó tribe in Brazil, founder of the city of Niterói Martim Afonso, baptismal name of Tibiriçá (died 1562), Brazilian Amerindian leader Mor Afonso, baptismal name of Madragana (c. 1230–?), mistress of Afonso III of Portugal Nadir Afonso (1920–2013), Portuguese painter Nelson Afonso (1934–1982), Indian singer, composer, playwright and theatre director Nuno Afonso (born 1974), Portuguese footballer Osório Citora Afonso (1972–2026), Mozambican Catholic bishop Pedro Afonso (sprinter) (born 2007), Portuguese sprinter Ronaldo Afonso (born 2000), Santomean footballer Salomé Afonso (born 1997), Portuguese middle-distance runner Tommy Afonso (born 1960), Portuguese singer, theatre actor, composer and playwright Víctor Afonso (born 1971), Spanish football manager and former player Yves Afonso (1944–2018), French actor of Portuguese descent