Cuyugan is a Kapampangan language surname meaning "friendship". It comes from the Pampango word cuyug, meaning "friend", "chum" or "comrade". Notable people with the surname include:
Fides Cuyugan-Asensio (born 1931), Filipino coloratura soprano, director, librettist, TV host, translator, and teacher Justin Cuyugan (born 1980), Filipino actor Vivencio Cuyugan (1895–1971), Filipino politician and boxer Marvin Agustin (born 1979), Filipino actor, chef and entrepreneur Bryan Matthew Cuyugan Nepomuceno (born 1980), Filipino lawyer, politician and businessman