Prentiss is a surname, and may refer to:
Adella Prentiss Hughes (1869–1950; née Prentiss), American pianist and impresario Ann Prentiss (1939–2010), American actress Anna Marie Prentiss, American archeologist Arthur Prentiss (1865 – c. 1941), American photographer Benjamin Prentiss (1819–1901), Union Army general in the American Civil War C. J. Prentiss (Carolyn Jean Prentiss) (1941–2024), American politician from Ohio Ed Prentiss (1908–1992), American radio actor Edith Prentiss (1952–2021), American disability rights activist Elizabeth Prentiss (1818–1878), American songwriter, poet and author Elisabeth Severance Prentiss (1865–1944), American philanthropist and art collector George Prentiss (1876–1902), American baseball pitcher Henry Prentiss (1801–1859), American businessman John Holmes Prentiss (1784–1861), American newspaper publisher and politician from New York State Mara Prentiss (born 1959), American physicist Melodye Prentiss, 1968 Playboy model Paula Prentiss (born 1938), American actress, wife of Richard Benjamin Robert Prentiss (1936–2022), American politician Samuel Prentiss (1782–1857), American politician and judge from Vermont Seargent Smith Prentiss (1808–1850), American attorney and politician from Mississippi Suzanne Prentiss (born 1964), American politician from New Hampshire Theodore Prentiss (1818–1906), American lawyer and politician from Wisconsin Thomas Prentiss (1809–1895), American-Canadian merchant and politician Virginia Prentiss (c. 1832 – 1922), American nanny and community leader Willard Prentiss (1897–1959), American racing driver William A. Prentiss (1799–1892), American merchant and politician from Wisconsin
See also Prentis Prentice (surname)