Oxholm is a surname. Notable people with the surname include:
Frederik Oxholm (1801–1871), Danish military officer Kitty Oxholm, American politician Oscar O'Neill Oxholm (various people) Peter Lotharius Oxholm (1753–1827), Danish army officer Sophie Oxholm (1848–1935), Danish noblewoman Tom Erik Oxholm (born 1959), Norwegian speed skater
See also Oxhorn Oxenholme