2025 Winston-Salem Open – Doubles

Rafael Matos and Marcelo Melo defeated Francisco Cabral and Lucas Miedler in the final, 4–6, 6–4, [10–8] to win the doubles tennis title at the 2025 Winston-Salem Open.

Nathaniel Lammons and Jackson Withrow were the two-time reigning champions, but chose not to compete together this year. Lammons partnered Sadio Doumbia, but lost in the first round to Withrow and Jan Zieliński. Withrow and Zieliński lost in the second round to Cabral and Miedler.

Seeds