Roque González may refer to:
Roque González y de Santa Cruz (1576–1628), Guarani-Spanish Jesuit priest and martyr Roque González Garza (1885–1962), Mexican general and politician, acting president in 1915 (1918–1987), Argentine politician, governor of Chubut (1963–1965) (1931–2015), Mexican diplomat, ambassador to the Soviet Union (1972–1975)
See also Roque Gonzales, Rio Grande do Sul, municipality of Brazil San Roque González de Santa Cruz, city in Paraguay