Manuel Castro may refer to:
Manuel Castro Almeida (born 1957), Portuguese lawyer and politician Manuel Castro Ruiz (1918–2008), Mexican Bishop of the Roman Catholic Church Manuel Castro (footballer) (born 1995), Uruguayan professional footballer Manuel Castro (water polo) (born 1923), Mexican water polo player Manuel Castro y del Valle (born 1944), Mexican politician
See also Manuel de Castro (1885–1944), Spanish sports journalist, football executive, manager, referee, and politician Manoel de Castro Villas Bôas (1907–1979), Brazilian entrepreneur, writer, and journalist